An abstract from the journal, Cell…
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contribution to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging with minimal side-effects.
Read full version here
My thoughts…
While this is a slightly dated article, it lays a solid foundation of our understanding of aging. There are many brilliant scientists working to reverse the hallmarks of aging. In the meantime, we can do our best to fight aging by…
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Eating foods that are in their natural form; vegetables, nuts, seeds, meats, fish, and fruits, in this order; eating a full spectrum of them at levels that support exercise but not body fat. Fasting at least 12 hours per day.
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Exercise. At least 150-300 minutes of moderate or 75 minutes of vigorous physical activity per week, with twice-weekly resistance training.
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Sleeping at least the same 7 hours every night.
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Use supplements with data to support their impact on longevity.
A few of my favorite supplements…
